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doi: 10.1006/viro.2002.1639

doi: 10.1038/s41598-018-28449-z 134 BertilssonGPatroneCZachrissonOAnderssonADannaeusKHeidrichJet al

BruceJPToKFLuiVWYChungGTYChanYYTsangCMet al

This could create disparities in access to these potentially beneficial therapies

While initial experiments demonstrated the involvement of endogenous peroxynitrite and protein tyrosine nitration in apoptosis of motoneurons in culture, further work in ALS animal models confirmed the formation of 3-nitrotyrosine and protein-derived radicals in spinal cord motor neurons during disease progression ( Table 1