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[10] [12] These interactions are supported by pharmacokinetic studies, clinical observations, and drug interaction databases

Vascular Inflammation: Active folate and B12 work synergistically to convert toxic homocysteine into beneficial methionine, reducing vascular inflammation and supporting healthy blood flow

A likely explanation is that it supports energy production, which the brain needs

This is supported by the observation that basal acidification and glycolytic reserve were at basal levels at 24 h, but the compensatory glycolysis was increased at this time point