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In this review, we discuss the roles of TDLNs in cancer metastasis, the impact of cancer cell progression and invasion on the LN immune microenvironment and the function of TDLNs in immunotherapy, as well as the opportunities and challenges in targeting LN metastasis for improving patient care

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On the immune front, gut microbiota can increase systemic inflammation by releasing lipopolysaccharides (LPS) and proinflammatory cytokines, and they also produce amyloids, which may stimulate neural amyloid production via immune priming

The liver is a key target of THs, with THs playing significant roles in liver disease pathogenesis such as alcoholic liver disease and non-alcoholic steatohepatitis [21, 22]

The Allen Human Brain Atlas (AHBA) database, an openly accessible repository, contains microarray data from tissue samples of six donors