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Physiological Responses to Cold Exposure When the body is exposed to cold water, several immediate physiological responses occur: Cold Shock Response : Sudden immersion in cold water triggers the cold shock response, characterized by rapid breathing, increased heart rate, and peripheral vasoconstriction

Similarly, high NRF2 activity promoted high levels of heme oxygenase 1 ( HMOX1 ), which acts detoxifying heme into biliverdin, releasing redox-active iron and, consequently, inducing lipid peroxidation in neuroblastoma [25] and fibrosarcoma cells [26]

The metalloid exerts its effect either by inhibiting enzyme function or by inducing oxidative stress 12,13