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Alterations in external conditionssuch as dietary factors, chemical exposures, and psychological stressorsor cellular stress can induce changes in epigenetic marks, leading to gene transcription activation or silencing

Mitochondrial serine metabolism supports purine nucleotide synthesis, conferring 5-FU resistance by mitigating DNA damage, conversely, serine deprivation sensitizes CRC to 5-FU (193)

Maintain a clean routine by avoiding synthetic fillers and choosing third-party tested brands

As IIF on rodent tissues is not universally available, an update of the simplified IAIHG criteria has been proposed recently by a European study aiming at evaluating the performance of a score including ANA tested on HEp2 cells and SMA tested by ELISA in adult patients [48]

This action helps regulate the hypothalamic-pituitary-gonadal (HPG) axis, which is crucial for maintaining reproductive hormone levels