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doi:10.1007/s40265-020-01256-5 62Laharie D, Bourreille A, Branche J, et al

GLP-1 receptor agonists have become a leading treatment option for weight management, with clinical trials showing an average weight loss of 15-22% over 68 weeks

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Additional risk factors include: Chronic kidney disease : Reduced renal clearance may impair B12 excretion Liver disease : Hepatic dysfunction can disrupt B12 metabolism and storage Myeloproliferative disorders : Certain blood cancers increase B12-binding proteins Concurrent medication use : Some drugs may interact with B12 metabolism, including metformin, proton pump inhibitors, and H2 antagonists Patients with these conditions should have B12 supplementation carefully monitored by their healthcare team