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The first principle in mushroom fermentation lies in exploiting carbohydrates, the most abundant component in most mushroom including glycogen, chitin, and glucans, trehalose and xylans, as raw material to digest them using lactic acid fermentation (Jaboska-Ry et al., 2019a, 2019b, 2019c, 2019d)

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Also, in the late phase of M1 macrophage polarization, lactate-derived lactylation of histone lysine residues as observed in conditions of hypoxia and bacterial challenges served as an epigenetic modification that directly stimulated the expression of homeostatic genes that have been traditionally associated with M2-like macrophages (Zhang et al., 2019)

TMG serves as a methyl donor in the betaine-homocysteine methyltransferase (BHMT) pathway