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Attack on DNA may trigger cell apoptosis or gene mutation, affect the normal proliferation and differentiation of thyroid cells, further damage the synthesis and secretion of thyroid hormone, and eventually aggravate the hypothyroidism condition (Lushchak, 2014)

10.3389/fped.2022.839111 15 BhaskarA.KumarS.KhanM

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Apigenin (25, 50, 100 mg/kg/day) intragastric administration for 9-months increased the muscle fiber size in aged mice, associated with the reduction of oxidative stress and inhibition of autophagy and apoptosis (Wang et al