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The oxidation of amino acid residues, the subsequent formation of protein aggregates by cross-linking and the production of protein fragments may result in the loss of activity and inactivation of enzymes and metabolic pathways, finally ending up with cell death [12]

Tobacco and the global lung cancer epidemic

* Correspondence: Guiying You [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Altogether, as proposed in the model in Figure 8 , we conclude that the protein-reactive QIs of AQ mainly trigger ER stress, eventually leading to apoptosis in HepG2 cells

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