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[The Working Group noted that the limitations of the study included the use of a single concentration level, the lack of information on aberrant types and mitotic index, and the evaluation of cytotoxicity (by MTT assay), rather than cell replication.] However, in another study, a statistically significant increase in the frequency of chromosomal aberrations was also reported at all three tested concentrations (500, 1000, and 2000 g/mL) in human lymphocytes treated with aspartame for 24 or 48 hours (Renczoullari et al., 2004)

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"But I have seen improvement across the board, even in those patients who don't necessarily have a specifically low level." There are plenty of other ways to supplement with B12, from pills to energy drinks

The table summarises the types of nanoparticles their active reagents, applications in terms of targeting delivery in BBB, clinical status, and the disease in which it plays the role