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[46] Carotenoids also contribute to human health through mechanisms unrelated to provitamin A activity, such as antioxidant and anti-inflammatory actions and photoprotection

doi: 10.1016/j.cell.2024.06.026 23

For example, elevated TXNRD1 was correlated with anti-PD1 resistance in head and neck cancer [285]

HIF1A overexpression is associated with malignancy and poor prognosis in esophageal or head and neck squamous cell carcinoma patients under platinum-based chemotherapy (Supplementary Table S1)