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The relative prevalence of these pathways in the regulation of cell death is not definitively established

Most neuroendocrine cancer cells are glycolytic in nature and contain fragmented mitochondria with low membrane potential (107)

SAH binds to some methyltransferases stronger than SAM, and the K i value of SAH reported could be as low as sub-micromolar range (Table 3) (Petronikolou and Nair 2015)