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The ferroptosis inducers such as glutamate, erastin are able to drain GSH and inactivate the enzymatic activity of GPX4 via blocking the import of cystine by the cystine/glutamate antiporter (system X c ) [27, 28] (Fig

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(XLSX 157 kb) Source data Rights and permissions About this article Cite this article Hangauer, M., Viswanathan, V., Ryan, M

Intracellular ATP Levels Are a Pivotal Determinant of Chemoresistance in Colon Cancer Cells

They are also the most promising compounds showing this action, as they play a major role in the induction of apoptosis