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IL-1R deficient mice are almost completely resistant to AILI [179], and the use of recombinant human IL-1R antagonists also has a protective effect on AILI [55]

However, individuals with MTHFR polymorphisms or low baseline homocysteine metabolism may benefit from precautionary methyl donor support

37 There is evidence of antigen presentation by eosinophils in some experimental murine models 37, 38 and of major histocompatibility complex class II expression by human eosinophils under certain conditions