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[DOI] [PubMed] [Google Scholar] Ogita K, Enomoto R, Nakahara F, Ishitsubo N, Yoneda Y

Preclinical and clinical studies demonstrate BBRs multimodal anti-obesity mechanisms: (i) adenosine monophosphate-activated protein kinase (AMPK) activation enhancing lipolysis and -oxidation, (ii) peroxisome proliferator-activated receptor (PPAR-) suppression inhibiting adipogenesis, (iii) gut microbiota modulation improving metabolic endotoxemia, and (iv) uncoupling protein 1 (UCP1) upregulation promoting adipose browning

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stenting with PDT versus stenting alone for unresectable CCA showed a marked survival benefit with the addition of PDT

The dynamic nature of this progression and multiple triggering factors make it difficult to describe the exact mechanisms underlying NAFLD