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analyzed mutations in 232 genetically-profiled NSCLC patients and found that about half of the local recurrences, post-radiotherapy occurred in tumors with KEAP1/NFE2L2 mutations, indicating these mutations are major drivers of clinical radioresistance [25]

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(B) Prolonged use raises deficiency risk

These cells appear to contribute to the aging process and age-related diseases through the senescence-associated secretory phenotype (SASP), which fosters a pro-inflammatory environment detrimental to tissue function and integrity

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