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IMCA treatment reduces CRC cell viability in vitro , inhibits the growth of xenografted CRC cells in vivo , and is associated with a decrease in the phosphorylation of mTOR and its downstream target P70S6K (125)

This pronounced localisation may be explained by (1) a high diversity of specialised microhabitats in fragmented landscapes 30,31 and/or (2) uneven survey efforts or incomplete samplings

UPS can interact with other systems and certain E3 ligases can play a role in a variety of diseases

Valenti D, Manente GA, Moro L, Marra E, Vacca RA