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Acknowledgements This work was supported by grants NIH R35HL135828 (Y.-J.H.), NIH R01HL137268, R01HL085646, R01HL138708, R21AG055325 (Av.dV.), NIH R01HL122383 and R01HL141364, RO1HL136917 (V.A.)

The peptide portion demonstrates high affinity for copper(II) ions, forming a stable chelation complex through coordination with the histidine imidazole nitrogen and the terminal amino group of lysine

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Sleep and Recovery: Ghrelin receptor agonists like MK-677 are linked to deep sleep (slow-wave Stage 3) a point of curiosity for MK-777 studies

Four research areas dominate: tendon and ligament repair, gastrointestinal mucosal healing (ulcer and IBD models), muscle and soft tissue recovery, and neuroprotection across stroke, TBI, and demyelination models