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Lipotropics enhance this process by supporting the methylation reactions required to convert fat into transportable forms and by preventing hepatic lipid accumulation that can slow metabolic throughput

95% CI, 5.21 to 1.23

Phase 2 trial data published in 2023 in the New England Journal of Medicine (Jastreboff et al., NEJM 2023) reported mean weight reductions of up to approximately 24% over 48 weeks in adults with obesity notably higher than results seen with currently approved agents

Daich Varela M, Jani P, Zein WM, DSouza P, Wolfe L, Chisholm J, Zalewski C, Adams D, Warner BM, Huryn LA, Hufnagel RB (2020) The peroxisomal disorder spectrum and Heimler syndrome: deep phenotyping and review of the literature

Expression of arginase I in macrophages is induced by the cytokines IL-4 and IL-13