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In addition, hypoinsulinemia in T1DM stimulates hepatic synthesis of IGFBPs, resulting in increased IGF-binding capacity and, consequently, reduced IGF-1 bioactivity which further stimulates GH-secretion [190192]

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doi: 10.2527/jas.2011-4358 34 MavalliMDDiGirolamoDJFanYRiddleRCCampbellKSvan GroenTet al

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