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Peer review Peer review information Nature Communications thanks Cristina Al-Khalili Szigyarto and the other, anonymous, reviewers for their contribution to the peer review of this work

The initial evidence of the health benefits of omega-3 fatty acids, namely eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), came from Greenland Eskimos, who consumed a diet heavy in fish and had low rates of multiple sclerosis, asthma, type I diabetes mellitus and coronary heart disease

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Therapeutically, targeting ferroptosis focuses on damaging cell membrane lipids, while targeting cuproptosis centers on inducing mitochondrial proteotoxicity