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BBB integrity itself is compromised

WX: Writing original draft

The dysregulation of key catabolic substrates, such as KG, creatine, fumarate and lactate, aligns with previous research indicating long-term disruptions in energy and mitochondrial metabolism in survivors of COVID-19 [13, 64, 65]

Studies by Hal Dvoraks group indicate that tumor blood vessels are heterogeneous consisting of at least six distinctly different blood vessel types: (1) mother vessels, (2) glomeruloid microvascular proliferations, (3) vascular malformations, (4) capillaries, (5) feeder arteries (6) and draining veins [19, 20]

Burdon, C.A., M.W