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Glossary LS Lynch Syndrome EC Endometrial cancer CRC Colorectal Cancer MMR Mismatch Repair MSS Microsatelite Stable MSI Microsatelite Instability MSI-H Microsatelite Instability-High MSI-L Microsatelite Instability-Low MLH1 MutL homolog 1 MLH2 MutL homolog 2 MSH2 MutS homolog 2 MSH6 MutS homolog 6 PMS1 PMS1 homolog 1 PMS2 PMS1 homolog 2 EPCAM Epithelial Cell Adhesion Molecule PTEN Phosphatase and Tensin Homolog TGF-R2 Transforming growth factor, beta receptor II BAX BCL-2-associated X protein HR Hazard Ratio PD-1 Programmed Death 1 PD-L1 Programmed Death Ligand 1 KRAS Kirsten rat sarcoma viral oncogene homologue PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha BMI Body Mass Index APC Adenomatous polyposis coli CTNNB1 Catenin beta-1 PCOS Polycystic ovary syndrome HRT Hormone Replacement Therapy IBD Inflammatory Bowel Disease TCGA The Cancer Genome Atlas DEGs Differentially Expressed Genes LS-CRC Lynch Syndrome Associated Colorectal Cancer LS-EC Lynch Syndrome Associated Endometrial Cancer COL11A1 Collagen Type XI Alpha 1 Chain SG-LC Specific Genes overlaps LS and CRC SG-LE Specific Genes overlaps LS and EC CST2 Type 2 cystatin COL18A1 Collagen Type XVIII Alpha 1 Chain LY6K Lymphocyte Antigen 6 Family Member K MIR27B MicroRNA 27b SST Somatostatin KIF20A Kinesin-like protein NUF2 Kinetochore protein Nuf2 HTR4 5-Hydroxytryptamine receptor 4 CDC45 Cell Division Cycle 45 WDR31 WD Repeat Domain 31 AADACL2 Arylacetamide Deacetylase Like 2 DHRS7C Dehydrogenase/Reductase 7C KRT24 keratin gene LINC00460 Long Intergenic Non-Protein Coding RNA 460 NPY2R Neuropeptide Y receptor type 2 KHDRBS2 KH RNA Binding Domain Containing, Signal Transduction Associated 2 CDH10 Cadherin 10 LINC02616 Long Intergenic Non-Protein Coding RNA 2616 LINC02691 Long Intergenic Non-Protein Coding RNA 2691 IGF2-AS IGF2 Antisense RNA IGF Insulin-like growth factor ADAMTS9-AS2 ADAM Metallopeptidase With Thrombospondin Type 1 Motif 9- Antisense RNA 2 SLC10A4 Solute Carrier Family 10 Member 4 EECs Endometrioid Endometrial Carcinomas BHD BirtHoggDub syndrome IGFIIR Insulin-like Growth Factor II Receptor Rad3 A yeast homolog of human ATR ATR Ataxia Telangiectasia and Rad3-related protein PIK3R1 Phosphoinositide-3-Kinase Regulatory Subunit 1 BRAF B-Raf Proto-Oncogene, Serine/Threonine Kinase FGFR2 Fibroblast Growth Factor Receptor 2 ARID1A AT-Rich Interaction Domain 1A BAF250a BRG1-Associated Factor 250a SWI/SNF SWItch/Sucrose Non-Fermentable ERBB2 Erb-B2 Receptor Tyrosine Kinase 2 PPP2R1A Protein Phosphatase 2 Scaffold Subunit A Alpha PP2A Protein Phosphatase 2A HER-2 Human Epidermal Growth Factor Receptor 2 RASSF1A Ras Association Domain Family Member 1 isoform A CDKN2A Cyclin Dependent Kinase Inhibitor 2A C-MYC MYC Proto-Oncogene, BHLH Transcription Factor MEST Mesoderm Specific Transcript HOXA10 Homeobox A10 HOXA11 Homeobox A11 SOCS3 Suppressor of Cytokine Signaling 3 GSK-3B Glycogen Synthase Kinase 3 Beta CCND1 Cyclin D1 SIR Standardized Incidence Rate CI Confidence Interval TP53 Tumor Protein P53 AURKA Aurora Kinase A CART Cocaine- and Amphetamine-Regulated Transcript E2F2 E2F Transcription Factor 2 (involved in cell cycle regulation) SNP Single Nucleotide Polymorphism MUTYH MutY DNA Glycosylase BER Base Excision Repair OGG1 8-Oxoguanine DNA Glycosylase CIMP CpG Island Methylator Phenotype HE4 Human Epididymis Protein 4 CA125 Cancer Antigen 125 PR Progesterone Receptor ER Estrogen Receptor FIGO International Federation of Gynecology and Obstetrics CDX2 Caudal Type Homeobox 2 Ki67 Marker of Cellular Proliferation TH Total Hysterectomy LS Laproscopic Surgery RS Robot-assisted Surgery BSO Bilateral Salpingo-Oophorectomy RS Recurrence Score EZH2 Enhancer of Zeste Homolog 2 FDA Food and Drug Administration dMMR Deficient Mismatch Repair 5-FU 5-Fluorouracil OX Oxaliplatin IRI Irinotecan NGS Next-Generation Sequencing References 1

Even today after Phase III trials have been published, which showed the adenovirus vaccine was 91.6% effective at preventing symptomatic COVID-19 infection and 100% effective at preventing sever infection, some scientists have criticized the authors for failing to provide full access to the raw data . 3 Almost one year later from its release, the Russian vaccine has been approved for use in 67 countries, however it has yet to gain EUA from the WHO

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doi: 10.1007/s00344-024-11476-8

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