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However, this particular dose is indicated for sleep-related pathologies such as jet-lag and works by targeting the central nervous system where canonical melatonin receptors are abundantly expressed (69)

While some studies report positive outcomes, the overall evidence remains mixed and somewhat controversial

These include: Older adults, as they absorb B12 less easily Vegetarians and vegans, because B12 is mostly in animal products People with stomach problems like celiac disease or Crohns disease Those who have had gastric bypass surgery Knowing these risk factors helps find who might need to check their B12 levels

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