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In PD models, evidence suggest that ablation of necroptosis effectors can attenuate inflammation and necrosis caused by neuroinflammation driven by agents like LPS or MPTP (Geng X

Taipale M, Krykbaeva I, Koeva M, Kayatekin C, Westover KD, Karras GI, Lindquist S

There is no curative treatment for PD has been developed so far, a mater that opens the door for continuous inputting efforts to reach a therapeutic goal

3a, dotted line) corroborated these histological findings evident by decreased numbers of PDGFR + OPCs and pre-mature O4 + OLs in DA Gsta4 compared to DA Wt (Supplementary Fig