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Intramuscular Injection Protocol The treatment involves giving 1 mg of B12 through muscle injections several times a week

Fat cells get larger, skin gets thinner and a little looser and the fibrous bands under the skins surface get thicker, leading to a dimpled appearance

Patients with established B12 deficiency who continue metformin therapy require more frequent monitoring to ensure replacement therapy maintains adequate levels

Evidence of phagocytosis of lipid-like material was noted in a vessel injected with EO 2.5% at 48 hours ( Fig