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Deficient glutamate clearance drives neuronal damage in neurotoxic disorders such as WernickeKorsakoff encephalopathy or hepatic encephalopathy 137,138,139 , whereas diminished K + buffering together with insufficient glutamate clearance leads to spreading depression, migraine and epilepsy 140,141,142

This study also suggests a role for the mitochondria, a known source of reactive oxygen species, in the pathogenesis of salt-induced vascular dysfunction and the potential benefits of direct activation of NRF2-mediated antioxidant defenses in ameliorating mitochondrial oxidant stress in HS-fed animals

Cohort 2: Everolimus-Treated metastatic cohort comprised patients with metastatic ccRCC (mRCC) who had progressed following prior systemic therapy and subsequently received Everolimus treatment

It is commonly prescribed in cases of anemia, neuropathy, weakness, and B12 deficiency-related disorders