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Therefore, learning how to control the plasticity of immunomodulation by NAD + may provide an important new modality for better therapeutic application of NAD + biology, as well as further understanding of the role of NAD + homeostasis in different types of inflammatory diseases

Metabolomics data of biological samples were acquired using a Vanquish UHPLC coupled to an Orbitrap Exploris 480 (ThermoFisher Scientific, United States) using Xcalibur (version 4.4.16.14, Thermo Fisher Scientific, USA)