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Salvianolic acid B (SalB), a polyphenolic compound from Salvia miltiorrhiza , improves mitochondrial function in MPP+-treated N2A cells by restoring mitochondrial membrane potential, reducing ROS production, enhancing mitochondrial biosynthesis, and activating the AMPK/SIRT3 signaling pathway (Zhao et al

In this line, GSH depletion in glial cells, including astrocytes, leads to neuroinflammatory phenotype (Lee et al., 2010)

The directionality of serine/glycine conversion is also an important factor in cancer cell metabolism and evidence suggests that mitochondrial SHMT2 is the major serine-to-glycine conversion enzyme in this context (Lewis et al, 2014)

Phase II Liver Detoxification Pathway Phase II liver detoxification neutralizes the byproducts of Phase I liver detoxification and other remaining toxins

The tests of said evaluations are well known to those skilled in the art and know how to correlate the activities studied and the results with the therapeutic activities and in vivo