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J Clin Invest (2001) 107:81322

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The combination treatment effectively delayed tumor growth and blocked EGFR by decreasing the phosphorylation of STAT3, p38 MAPK, ERK1/2, and BAD proteins, while the IC 50 value of CHE was between HCC827 (IC 50= 5.0 0.48 M), SK-MES-1 (IC 50= 6.35 1.26 M), and A459 (IC 50= 7.78 0.56 M) ( These studies provide a new perspective on the anticancer therapeutic strategy of CHE in combination therapy

Martinez G, Hograindleur J-P, Voisin S, Abi Nahed R

Frente a la somatropina exgena, que introduce GH recombinante directamente, este blend acta de manera indirecta estimulando a los somatotropos para que liberen su propia GH, preservando los mecanismos de retroalimentacin endgenos