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Upon a second NIR irradiation, the local temperature reached 42, triggering DNAzyme conformational changes that enabled real-timein situ fluorescence imaging of AO and Ca 2+ concentration

Additional information Journal peer review information: Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work

Immediately following excision, tumour specimens were delivered to Surgical Pathology and reviewed by certified pathologists at the University of Rochester Medical Center, who allocated remnant malignant tissue for research

Gut dysbiosis-induced overproduction of LPS and peptidoglycans potently activates innate immune receptors, driving systemic inflammation that can breach the BBB and exacerbate neural damage (Kesika et al., 2021)

Patient subgroups, characterized by distinct symptom profiles and comorbidities, exhibited increased responses to specific treatments, e.g., a POTS-dominant cluster benefiting from autonomic modulators and a cognitive-dysfunction cluster from CNS stimulants