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However, A 20 years longitudinal follow-up of a Jamaican birth cohort demonstrated that individuals with HbSC disease have a significantly higher risk of developing proliferative sickle cell retinopathy compared to those with HbSS [34]

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19 Peri-prosthetic joint infections +/- lack of osteointegration can be devastating, leading to early joint revision surgery with poorer outcomes and much higher rates of post-operative complications and higher costs