(Nature Communications 2025) mapped cagrilintide binding to amylin and calcitonin receptors structurally
The problem: Even a little fakery is a major no-no
Abbreviations AKI: Acute kidney injury ARN: Acute radiation nephropathy ACE: Angiotensin-converting enzyme AT I: Angiotensin I AT II: Angiotensin II BED: Biologically effective dose BMT: Bone marrow transplantation CKD: Chronic kidney disease CRN: Chronic radiation nephropathy DSB: Double-stranded breaks DAMP: Damage-associated molecular patterns EETs: Epoxyeicosatrienoic acids H&E: Hematoxylin and eosin IMRT: Intensity modulated radiotherapy MRT: Magnetic resonance tomography NO: Nitric oxide QUANTEC: Quantitative Analyses of Normal Tissue Effects in the Clinic RAAS: Reninangiotensinaldosterone system RN: Radiation nephropathy RT: Radiotherapy ROS: Reactive oxygen species OS: Oxidative stress TBI: Total body irradiation TGF-: Transforming growth factor beta TMA: Thrombotic microangiopathy VMAT: Volumetric arc therapy References Wild CP, Espina C, Bauld L, Bonanni B, Brenner H, Brown K, et al

It's a small peptide made from three amino acids (cysteine, glutamic acid, and glycine) produced in every cell, with the highest concentrations in the liver
Read Karen Careys report in BioWorld News (free with one-time registration): #biopharma #cardiovascular #clinicaldata #phaseIII #smallmolecule Clarivate for Life Sciences & Healthcare To view or add a comment, sign in Congratulations to #TBCPartner Edgewise Therapeutics on their recent positive top-line results from the Phase 2 CIRRUS-HCM trial