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Seeler, J.S

The results of a series of studies have shown that caffeine at routine intake levels appears to have little effect on IOP and glaucoma risk in the general population

Biochemical Basis of Thiamines Cellular Role Dietary Availability, Absorption, and Cellular Uptake As with most hydrophilic micronutrients, thiamine absorption occurs mainly in the jejunum (33)

This means that if you drink lots of coffee or use other stimulants for medical reasons, L-theanines calming effects may help reduce wakefulness, jitters, etc