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[PubMed: 16456101] 364

Moreover, mitochondrial damage elevates ROS levels (380), which can in turn damage mtDNA and proteins that may be involved in the electron transport chain (ETC), resulting in lowered ATP production and decreased energy levels (381)

Because of their potency, they must be used with care, especially when layering, to avoid irritation or neutralizing their effects

The dynamic effects of isosteviol on insulin secretion and its inability to counteract the impaired -cell function during gluco-lipo-and aminoacidotoxicity: studies in vitro