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Ahmed, A, Colon, S, Dafflisio, GJ, Kothari, P, Uzoigwe, N, Zhou, A, Buchwald, J, Sharew, B, Glenn, C, Medvedovsky, S, Olivera, JA, Kramer, R, Colon, G, Tomasko, JM, Pereira, SJ, Antonoff, MB , Pelletier, M, Hameed, I

Neurotoxicology 30, 977985

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Exposure to propofol during early postnatal development significantly elevates the expression of pro-inflammatory markersincluding caspase-1 and interleukin-1in both cortical and thalamic regions of postnatal day 7 rats (Milanovic et al

Additionally, the mechanism by which the two treatments exert their beneficial effects remains unclear