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According to the NCCN ( Figure 1 Histologic confirmation of disease: This includes a confirmed diagnosis of grade 1, endometrioid adenocarcinoma limited to the endometrium (Stage IA), or AEH, based on endometrial ( Absence of myometrial invasion or metastasis: Imaging studies (MRI preferred) should confirm that the disease is confined to the endometrium, with no evidence of myometrial invasion, cervical involvement, or distant metastasis ( Patients should have no contraindications to hormonal therapy: This includes evaluating the patients medical history for contraindications to progestins or other hormonal treatments ( Strong patient commitment to follow-up: Patients need to be highly compliant with close follow-up, as fertility-preserving treatment requires ongoing monitoring of the disease ( The cornerstone of fertility-preserving treatment in both AEH and early-stage EC is hormonal therapy

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The nasal route facilitates non-invasive administration, avoiding the need for injections or complex delivery systems, which may simplify protocol designs during experimental procedures

We also examined condensin distribution in cells depleted of endogenous Cnd2 and expressing wild-type or mutant Cnd2 from plasmids (Supplementary Fig

Goss, K