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Clinicians: persistent cytokine signaling, immune cell infiltration, and progressive interstitial fibrosis impair glomerular and vascular function

APAP toxicity is also observed in people with alcohol use disorder (AUD), possibly due to upregulated CYP2E1 activity [282, 286, 287] or a response to fasting [288] (which is known to decrease GSH levels and increase CYP2E1 [202])