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On the other side, the hydrophobicity of carotenoids limits their pharmaceutical uses, they need a suitable nanosystem to reach their target with higher activity 41,42

The model was refined to 1.85 in space group P 2 1 2 1 2 1

While additional studies are needed to determine whether elevated vitamin B 12 status may be related to cancer development, including evaluating whether it might be a potential marker of cancer, it is important for observational studies to adequately control for potential confounders, such as age, menopausal status, alcohol use, and intake of the B-vitamin folate

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