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Description

Barcik, W., Boutin, R

Macroautophagy/autophagy promotes resistance to KRAS(G12D)-targeted therapy through glutathione synthesis

The best inhibitor with an IC 50 value approximately 2 times lower than for ebselen was 2-(5-chloro-2-fluorophenyl)-1,2-benzisoselenazol-3(2 H )-one

By monitoring for the appearance of the ~9 kDa C3a fragment, no cleavage products could be detected, suggesting that Chi homologs did not exert C3b/C3 cleavage activity under the tested conditions