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Both Botox and Dysport are Health Canada-approved neuromodulators, but they differ in key ways

358 Abnormal expression of transport proteins/receptors in the BBB, such as downregulation of LRP1 which exports A from the brain to the blood, impaired function of Pgp, and upregulation of RAGE that facilitates the entry of A from the blood into the brain, could be potential reasons for impaired A clearance and substantial accumulation in the brain

Figure 7 Genome-wide cytosine methylation changes in an HD model were first observed in mouse striatal neurons expressing either pathogenic (STHdhQ111) or normal (STHdhQ7) polyQ domains

doi: 10.3389/fendo.2023.1050540 40 KovacicJCDimmelerSHarveyRPFinkelTAikawaEKrenningGet al

Plant-derived anticancer compounds as new perspectives in drug discovery and alternative therapy