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High doses of caffeine and sugar can raise cortisol, narrow blood vessels, and increase oxidative stress a buildup of free radicals that damages sperm DNA

Mol Psychiatry 15 : 501511

Watters et al., 2016)

Critical parametersincluding particle-size distribution, surface charge, and degradation productsmust be quantified through validated, standardized assays to guarantee batch-to-batch consistency and clinical reproducibility ( Figure 4 )