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Large doses of B12 can trigger acne-like symptoms in a small percentage of people

Those who have had bariatric surgery or have malabsorption issues might need special dosing plans

Who is at risk for Vitamin B12 deficiency

Among these patients, 3 experienced disease progression (PD) during the first treatment cycle, 2 had stable disease, and 2 developed PD after having achieved response (1 partial response [PR] and 1 very good partial response [VGPR]) ( Supplementary Figure S1 )

Overall, these results reinforce the security of the 1 nM dose of B12 and prove its efficiency in regulating the mRNA levels of several critical inflammatory mediators in whole blood cultures of patients with moderate and severe COVID-19