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Glucagon receptor activation increases hepatic glucose production (relevant for energy balance), boosts basal metabolic rate (thermogenesis), and promotes lipolysis (fat breakdown)

Both terms describe a purified, nonpyrogenic, preservative-free aqueous preparation used to dissolve or dilute injectable medications

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A companion study by Ng and colleagues in the Journal of Molecular Endocrinology examined AOD9401 in Zucker fatty rats and reported enzyme-level effects on hormone-sensitive lipase and acetyl-CoA carboxylase consistent with the dual antilipogenic and lipolytic model developed at Monash [4]

M1 was found to be less potent in inhibiting the dopamine transporter compared to tesofensine, and it reached higher concentrations in the body when compared to tesofensine