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Nat Commun 11(1):5332, 2020

Specifically, a stringent selection based on variable importance in projection (VIP), fold change (FC), and statistical significance unveiled 14 significantly upregulated metabolites (Figure 5C), with patterns further explored in heatmaps and chord diagrams

When heptanoate is metabolized by -oxidation, it generates two molecules of acetyl-CoA and one molecule of propionyl-CoA

In fact, cationic LNPs can directly interact with the negatively charged DNA, allowing them to safely protect genetic materials and facilitating effective gene transfection into cells, which makes LNPs a promising system for gene delivery [196, 197]