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Drug Interactions Drug Interactions Affecting Co-administered Drugs: Antibiotics: Thiamine, riboflavin, pyridoxine, niacinamide and ascorbic acid decrease activities of erythromycin, kanamycin, streptomycin, doxycycline and lincomycin (7.1) Bleomycin: Ascorbic acid and riboflavin may reduce the activity of bleomycin (7.1) Levodopa: Pyridoxine may decrease blood levels of levodopa and levodopa efficacy may decrease (7.1) Phenytoin: Folic acid may decrease phenytoin blood levels and increase risk of seizure (7.1) Methotrexate: Folic acid may decrease response to methotrexate (7.1) Drug Interactions Affecting Vitamin Levels: Use In Specific Populations See 17 for PATIENT COUNSELING INFORMATION

A summary of the known activities of vitamins in the nervous system is provided in Supplementary Tables S1, S2

Still, the lack of long term data means no peptide is completely risk-free

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