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The antioxidative DAN is successfully prepared by embedding Fe and Mn bimetallic single-atoms in N-doped carbon material and modifying it with a hydrophilic polymer

Through the activation of the butyrate-GPR109A signaling axis, this combination therapy effectively inhibits NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and reduces renal IL-18 secretion, providing additional renoprotection in DN (107, 113)