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Skin improvements from GHK-Cu tend to develop more gradually, with noticeable changes in firmness and texture typically appearing around weeks 4 to 8

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Its deficiency is responsible for the dysfunction of the endothelial system

doi: 10.1038/onc.2009.422 383 AntonyakMAWilsonKFCerioneRA

Specifically, collagenase ointment is used primarily for wound care and is typically applied once or more daily for several days and requires days to weeks to effectively treat thermal burns