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Additionally, exposure to UV light acts as a potent inducer for expressing proopiomelanocortin (POMC)-derived peptides such as adrenocorticotropic hormone (ACTH) and -melanocyte stimulating hormone (-MSH) [92,93]

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Herein, we aimed at examining the hypothesis stating that the excitatory glutamatergic neurotransmissions were enhanced in the autistic brains in association with the astrocytic activation which is related to Gln synthesis and disrupted dopaminergic signals through D1Rs

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Structural comparison with Conformer 1 showed that there is a small but remarkable shift of the entire G i heterotrimer relative to the receptor with a ~15 rotation of the N-terminal -helix (N) and ~10 rotation of the C-terminal -helix (5) of G i in Conformer 2 (Fig