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Semaglutide (the GLP-1 half of CagriSema) and tirzepatide both agonize it, which is why both suppress appetite, slow gastric emptying, and improve glycemic measures

For some people, this is a significant disadvantage because appetite control is their primary challenge

For many peopleespecially those over 50 or with common genetic mutationsthat conversion process is inefficient, meaning you're not getting the benefits you paid for

It also boosts IGF-1, a compound that can help build lean muscle mass

This mechanism is based on the peptide's ability to stimulate the differentiation of stem cells into chondrocytes the cells that build cartilage tissue